Is it EFi ???
If so, try dis-connecting each of the injectors in turn and noting if there is any change to the engine note.
Unfortunately, it could be the injectors themselves playing up, in which case try swopping 2 over and see if the mis-fire moves with it.
However, the most common problem is worn camshaft lobes. Remove the rocker cover and see if the valves are opening by turning the engine over by hand.