I have one the same and bigger tyres make it worse, it's the extra strain of moving them.
IIRC in 5th the props and engine are at a similar speed,also the engine has the least mechanical adbantage over the wheels, but any vibration in the pros and engine harmonise worse than in any other gear.
Thing is I know I have a V7 on a bad day, it's eating a valve and I just don't have time to fix it, when I do roll on 4.6l of John Eals engine and an auto box :twisted: